Prodrome-Neuro validated in humans!

December 8, 2019

Successful first human trial of Prodrome-Neuro Plasmalogen Oil: a scientifically designed, natural, pure, synthetic plasmalogen precursor

Prodrome-Neuro Plasmalogen Oil is a synthetically pure, natural, plasmalogen precursor designed to elevate specific plasmalogens in the blood. Low levels of plasmalogens are associated with an increased risk of Alzheimer’s disease and early death. Six adults aged 23-56 took a single oral 100mg/kg dose (10-times the recommended daily dose) of Prodrome-Neuro Plasmalogen Oil and then plasmalogen levels were measured in blood samples at timed intervals. The target plasmalogen level significantly increased in every subject at 24 hours (p<0.001). The average 24-hour blood level was 180% of starting levels. As designed, non-targeted plasmalogens were not elevated. No adverse reactions were observed.

A daily 10mg/kg dose is projected to elevate plasmalogens to protective levels and to maintain healthy levels. This is the first time targeted plasmalogen elevation has been achieved in humans. Dr. Dayan Goodenowe, Founder and CEO of Prodrome Sciences, designed and developed Prodrome-Neuro to specifically elevate the precise plasmalogen species proven to be neuroprotective in animal studies and associated with lower rates of Alzheimer’s disease and increased longevity in humans.

Plasmalogens obtained from the diet are digested in the gut before they can be absorbed into the blood; therefore, it is not possible to elevate plasmalogens in the blood supply from dietary sources. Prodrome-Neuro is a pure, high dose plasmalogen precursor specifically designed to survive stomach acids and gut enzymes. In the liver, the product bypasses peroxisome metabolism (which is reduced in children with specific genetic diseases and in the elderly) and is then converted to the final target plasmalogen and then released into the blood for distribution throughout the body and to the brain.

Plasmalogens are critical lipid molecules that are part of neurons and the brain – they make up as much as 20% of the dry weight of the brain! Plasmalogen levels increase until about 30 to 40 years of age and then dramatically decline by around 70 years. There are no adequate food sources. Plasmalogens are made in the peroxisomes of cells and the majority are made in the liver.

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